Grand Rounds Prompt: Myasthenia Gravis and Immune Checkpoint Inhibitors
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Question: "Can you explain Myasthenia Gravis, particularly how it affects the neuromuscular junction and leads to fluctuating muscle weakness? I’d like a deeper look into how MG is diagnosed, with a focus on antibody testing like AChR and MuSK, and the role of treatments such as thymectomy, corticosteroids, and newer therapies like complement and FcRn inhibitors. Could you also elaborate on managing myasthenic crises, especially in cases triggered by immune checkpoint inhibitors in cancer therapy? Please provide evidence or recent studies that support these diagnostic and treatment approaches."