Long COVID Research Prompts

Provide a comprehensive analysis of POTS (Postural Orthostatic Tachycardia Syndrome) in post-COVID patients, including: 1. Detailed pathophysiology mechanisms and how they may differ from other causes of POTS 2. A practical step-by-step diagnostic algorithm for primary care providers, including specific testing parameters and when specialty referral is indicated 3. Evidence-based treatment protocol with specific medication dosing recommendations, titration schedules, and monitoring parameters for each medication class (beta blockers, midodrine, fludrocortisone, ivabradine, pyridostigmine) 4. Patient education resources and self-management strategies including the Levine Protocol 5. Potential long-term outcomes and prognosis based on current research Please include both pharmacological and non-pharmacological approaches, and address how to manage patients who don't respond to first-line therapies. Cite relevant research where available.

Provide a state-of-the-art review of Long COVID, covering: 1. Evolving diagnostic criteria and case definitions, including how they've changed since 2020 2. Current understanding of pathophysiological mechanisms, particularly focusing on: - Viral persistence versus viral clearance theories - Immune dysregulation and autoimmunity - Microbiome disruption - Endothelial dysfunction - Autonomic nervous system involvement 3. Cutting-edge research findings from major studies (RECOVER, etc.) and what they reveal about disease mechanisms 4. Diagnostic approach for primary care providers, including: - Minimum recommended workup - Differential diagnosis considerations - When to refer to specialty clinics 5. Evidence on viral persistence versus clearance - review recent studies on viral reservoir detection, ongoing viral replication, and implications for treatments like Paxlovid for long COVID 6. Management strategies that have shown promise in clinical studies, particularly examining antiviral approaches if viral persistence is suspected Include current research controversies and unanswered questions that may transform our understanding in the coming years.