Analyze the neurobiological underpinnings of gambling disorder, focusing on:
1. The complex interplay of brain circuits beyond simple dopaminergic reward pathways
2. The role of specific regions (ventral striatum, medial orbital frontal cortex, insula, lateral orbital frontal cortex, anterior cingulate, amygdala) in mediating distinct gambling behaviors:
* Reward sensitivity
* Loss-chasing
* Withdrawal symptoms
* Stress responses
3. How this circuit-based understanding can inform targeted interventions:
* Pharmacological approaches (naltrexone, glutamate modulators)
* Cognitive-behavioral strategies matched to specific neural dysfunctions
* Emerging neuromodulation techniques
Write in the style of a concise academic paper, avoiding both excessive jargon and oversimplification.
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