Grand Rounds Prompt: Exploring Vagal Neuropathy and Laryngeal Hypersensitivity
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Question: "Laryngeal hypersensitivity often involves complex neural reflex pathways and overlaps with conditions like GERD and asthma. How does the vagus nerve's role in laryngeal reflex sensitivity inform our understanding of chronic cough and inducible laryngeal obstruction (ILO)? Specifically, what are the emerging therapies targeting vagal neuropathy or hypersensitivity, and how do they compare in efficacy to traditional approaches like proton pump inhibitors and speech therapy? Furthermore, how can clinicians effectively disambiguate vagus nerve-mediated conditions from other overlapping disorders, such as asthma or reflux, to refine diagnoses and treatment plans?"